Shirdi sai have you authored this book on genome?- Part IV

The secret of life is indeed a thread...the earth and ocean were probably peopled with vegetable productions long before other families of them, shall we conjecture that one and the same kind of the living filaments is and has been the cause of all organic life?
How can a filament make something live? Life is a slippery thing to define, but it consists of two very different skills, ability to replicate, and the ability to create order. Living things produce the approximate copies of themselves. Rabbits produce rabbits, dandelions produce dandelions, but rabbits do more than that. They eat grass transform themselves....
The key for both of these features of life is information. The ability to replicate is made possible by the existence of the recipe, the information to create a new body. A rabbit’s egg carries the instruction for assembling a new rabbit. But the ability to create order through metabolism also depends on information....
These pieces of information get transcribed translated and synthesis protein which is the actual dogma of molecular biology....as that of selection and sequencing in computer programming....One thing for sure every thing right from machine to man needs selection, sequencing and execution.....isn’t it program ultimately ?
Aum sairam

Shirdi sai have you authored this book on genome? - Part II

This is a gigantic document, an immense book, a recipe of extravagant Length, and it all fits inside the microscopic nucleus of a tiny cell that fits easily upon the head of a pin. This book is a piece of digital information written in linear, one dimensional and one directional form and defined by the code that transliterates a small alphabet of signs into a large lexicon of meanings through the order of their groupings. So is the Genome.
only complication is that all English books are read from left to right, whereas some parts of the Genome read from left to right and some from right to left though never both at the same time
English books are written in words of variable length using twenty six letters, genomes are written entirely in three letter words, using only four letters, A, C, G, T which stands for (Adenine Cytosine Guanine and Thiamine)

Instead of being written on flat pages, they are written on long chains of sugar and phosphate called DNA molecules in which the bases are attached as side rungs, each chromosome is one pair of very long DNA molecules. This Genome book is a clever book because in the right condition it can both photocopy and read itself. The photocopying is known as REPLICATION. The reading is known as TRANSLATION
The messenger the RNA copy is the befriended by a microscopic machine called RIBOSOMES. These ribosome moves along the messenger translating each three letter CODON in turn into one letter of a different alphabet of twenty different amino acids. Each amino acid is attached to the last to form a chain in the same order as the CODON. Not all 64 three letter CODONS specifies an amino acid. Three signify stop CODON instead. And finally not all DNA spells out genes. Most of it is a jumble of repetitive or random sequences that is rarely or never transcribed: the so called junk DNA.
I had a cup of water in the middle of my presentation. A person came with a tray on it a bottle of mineral water. He placed it on my table and uttered sairam.....a sai devotee?
Aum Sairam

Shirdi sai have you authored this book on genome? - Part I

With the blessings of shirdi sai and praying to him I started my lecture in the big auditorium of 350 audiences belonging to various categories right from students to professors of various disciplines. Some are not scientist. I wanted one and all to know what I am talking about to make the Genome understandable and hence....

I started with a prelude about Scintillating Primo levi who did something similar with the periodic table of the elements in his autobiographical short stories. He related each chapter of his life to an element one that he had contacts with during the period he was describing.... The same way I read another interesting book on human Genome by Matt Ridley...In his book he says

“I began to think about the Human genome as a sort of autobiography. In its own right, A record written in “genitish,”of all the Vicissitudes and inventions that had characterized the history of our species and its ancestors since the very dawn of life.
Modern genetics is a formidable thicket of jargons.
The human body contains approximately 100 trillion cells. Most of them are less than a tenth of millimeter across. Inside each cell there is a black blob called a Nucleus. Inside the Nucleus are two complete sets of Human genome (Excepting in egg and sperm which has one and red blood cells which has none).One set of genome comes from the mother and other by the father. We are the result after swapping bits of the paternal and maternal chromosomes Called recombination

There are twenty three chapters, called CHROMOSOMES

Each chapter contains several thousands stories, called GENES

Each story is made up of paragraphs, called EXONS which are

Interrupted by advertisements called INTRONS

Each paragraph is made up of words, called CODONS

Each word is written is letters called BASES

There are one billion words in the book that means it makes it as long as 800 bibles. If I read the genome out to you @ one word per second for 8 hrs a day It would take me a centaury to finish reading the book If I write out the Human Genome @one letter per minute, my text would be as long as the river Danube...

After talking on the Human Genome I came and sat amidst a good applause. I was happy that many could appreciate...But I never did aarti to my sai yesterday that was working in my mind....totally into vingjnana (Science) ...that fascinated me....it is all like addiction. Some people get caught in agnana (not good action) and my sai who is a meignani (person with inner knowledge) will he relish it?

My sai only knows...

Aum Sairam