Thursday, January 17, 2008

Shirdi sai have you authored this book on genome? - Part II

This is a gigantic document, an immense book, a recipe of extravagant Length, and it all fits inside the microscopic nucleus of a tiny cell that fits easily upon the head of a pin. This book is a piece of digital information written in linear, one dimensional and one directional form and defined by the code that transliterates a small alphabet of signs into a large lexicon of meanings through the order of their groupings. So is the Genome.
only complication is that all English books are read from left to right, whereas some parts of the Genome read from left to right and some from right to left though never both at the same time
English books are written in words of variable length using twenty six letters, genomes are written entirely in three letter words, using only four letters, A, C, G, T which stands for (Adenine Cytosine Guanine and Thiamine)

Instead of being written on flat pages, they are written on long chains of sugar and phosphate called DNA molecules in which the bases are attached as side rungs, each chromosome is one pair of very long DNA molecules. This Genome book is a clever book because in the right condition it can both photocopy and read itself. The photocopying is known as REPLICATION. The reading is known as TRANSLATION
The messenger the RNA copy is the befriended by a microscopic machine called RIBOSOMES. These ribosome moves along the messenger translating each three letter CODON in turn into one letter of a different alphabet of twenty different amino acids. Each amino acid is attached to the last to form a chain in the same order as the CODON. Not all 64 three letter CODONS specifies an amino acid. Three signify stop CODON instead. And finally not all DNA spells out genes. Most of it is a jumble of repetitive or random sequences that is rarely or never transcribed: the so called junk DNA.
I had a cup of water in the middle of my presentation. A person came with a tray on it a bottle of mineral water. He placed it on my table and uttered sairam.....a sai devotee?
Aum Sairam

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